Nolicin tablets from which they are taken. Instructions for use of nolicin tablets, analogues, prices, reviews

Composition and form of release of the drug

Film-coated tablets orange, round, slightly biconvex, with a notch on one side.

From the side of the central nervous system: headache, dizziness, fatigue, sleep disturbances, irritability, anxiety.

Allergic reactions: skin rash, itching, angioedema.

From the side of the urinary system: interstitial nephritis.

drug interaction

With the simultaneous use of norfloxacin, the anticoagulant effect of the latter is enhanced.

With the simultaneous use of norfloxacin with cyclosporine, an increase in the concentration of the latter in the blood plasma is noted.

With the simultaneous administration of norfloxacin and antacids or preparations containing iron, zinc, magnesium, calcium or sucralfate, the absorption of norfloxacin decreases due to the formation of chelators with metal ions (the interval between their administration should be at least 4 hours).

When taken simultaneously, norfloxacin reduces clearance by 25%, therefore, with simultaneous use, the dose of theophylline should be reduced.

Simultaneous administration of norfloxacin with drugs with the potential to reduce blood pressure can cause a sharp decrease in blood pressure. In this regard, in such cases, as well as with the simultaneous administration of barbiturates, anesthetics, heart rate, blood pressure, ECG indicators should be monitored. Simultaneous use with drugs that reduce the epileptic threshold may lead to the development of epileptiform seizures.

What is the drug and what is it used for

Nolicin® is an antibacterial drug from the group of quinolones that destroys bacteria that are sensitive to it and cause diseases in the human body.
Nolicin® is used to treat:
- complicated and uncomplicated, acute and chronic infections of the upper and lower urinary tract caused by pathogenic microflora sensitive to norfloxacin
- bladder infections (including after surgery and accompanying neurogenic bladder)
- kidney infections
- prostate infections (chronic)
- infections associated with nephrolithiasis.

Do not take the drug

If you are allergic to norfloxacin, or any other quinolone medicines, or any of the other ingredients of this medicine (listed in the ingredients section);
- if you have had inflammation or tendon ruptures associated with taking antibacterial medicines (fluoroquinolones);
- if you are pregnant or breastfeeding.
Nolicin® should not be taken by children and adolescents.

Special instructions and precautions

Talk to your doctor before taking Nolicin®.
When taking fluoroquinolones, including norfloxacin, there were potentially irreversible serious adverse reactions from various body systems that could occur in the same patient. Commonly observed adverse reactions included tendonitis, tendon rupture, arthralgia, myalgia, peripheral neuropathy, and central nervous system effects (hallucinations, anxiety, depression, insomnia, severe headaches, and impaired consciousness). These reactions may occur within hours or weeks of starting norfloxacin. Adverse reactions have been experienced by patients of any age with or without pre-existing risk factors.
Before you start using Nolicin®, tell your doctor if you have the following conditions:
- If you suffer from epilepsy or other disorders of the central nervous system (especially disorders accompanied by convulsions). In such cases, side effects develop more often. Seizures have been reported in patients taking antibiotics such as norfloxacin. Side effects from the central nervous system may occur after taking the first dose of the drug. Stop taking Nolicin® and call your doctor right away if you experience any of these side effects or other changes in your mood or behavior: seizures, trouble sleeping, voice or sound hallucinations, nightmares, dizziness, feelings of anxiety or nervousness, suspiciousness (paranoia), tremors, suicidal thoughts or actions, headaches that do not go away, with or without visual disturbances, disturbances in consciousness, depression.
- Fluoroquinolones, including norfloxacin, are associated with an increased risk of tendinitis and tendon rupture in patients of all ages. This adverse reaction is most commonly associated with the Achilles tendon, and an Achilles tendon rupture may require surgical repair. Tendonitis and tendon rupture have also been reported in the rotator cuff (shoulder), arm, biceps, thumb, and other tendons. The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is increased in elderly patients, usually over 60 years of age, in patients taking corticosteroid drugs, and in patients who have undergone kidney, heart, or lung transplants. Tendon rupture may occur during or after completion of therapy; cases have been reported occurring within a few months after completion of therapy. Stop taking Nolicin® and seek immediate medical attention at the first sign of pain, swelling, or redness in the tendon area, or if you experience any of the following signs or symptoms of a tendon rupture: a sound or feeling of clicking or popping in the tendon area; bruising immediately after an injury in the tendon area; inability to move the affected area or lean on it. Avoid exercise and stress on the affected limb.
- If you have been diagnosed with enlargement or "dilation" of a large blood vessel (aortic aneurysm or peripheral large vessel aneurysm).
- If you have previously had an episode of aortic dissection (rupture of the aortic wall).
- If you have a history of aortic aneurysm or dissection, or other risk factors or predisposing conditions (e.g., connective tissue diseases such as Marfan syndrome, vascular-type Ehlers-Danlos syndrome, Takayasu's arteritis, giant cell arteritis, Behcet's disease, arterial hypertension, atherosclerosis).
- If you have severe kidney failure. Your doctor will evaluate the advantages and disadvantages of using Nolicin® on a case-by-case basis (see How to take this medicine) and will lower your dose if necessary.
- During treatment with Nolicin®, hypersensitivity to sunlight or artificial ultraviolet light may develop. Therefore, it is recommended to avoid excessive exposure to sunlight and artificial ultraviolet light.
- If you have a deficiency of glucose-6-phosphate dehydrogenase, in rare cases, when taking Nolicin®, hemolytic anemia (destruction of red blood cells) may develop.
- If you have myasthenia gravis (muscle weakness; see section "Possible adverse reactions"). Norfoxacin may exacerbate (possibly as yet undiagnosed) myasthenia gravis, resulting in life-threatening respiratory muscle weakness. Nolicin® should not be used in patients with myasthenia gravis.
- When taking norfloxacin, serious, potentially life-threatening hypersensitivity reactions (anaphylactic and anaphylactoid) may develop, which may occur after the first dose (see section "Possible adverse reactions"). If you notice swelling of the skin, mucous membranes in the face and mouth, you have breathing problems, Nolicin® should be stopped immediately, you should consult a doctor or call an ambulance for emergency assistance.
- Since crystals may form in the urine (crystalluria) when taking Nolicin®, it is necessary to drink enough fluids, especially during long-term treatment, which should be monitored by a doctor. Ask your doctor how much fluid per day is enough for you.
- The occurrence of severe and prolonged diarrhea during or after treatment may be a sign of the very rare pseudomembranous colitis. In this case, treatment with Nolicin® should be discontinued and a doctor should be consulted.
- Special attention is required when taking Nolicin® if you or a member of your family has a long QT syndrome (on an ECG, an electrocardiogram of the heart), with an impaired electrolyte balance (especially with low levels of potassium and magnesium in the blood), with a very slow heart rate (bradycardia), if you have heart disease (heart failure), if you have an acute cardiovascular disease (myocardial infarction), if you are a woman or an elderly person, or if you are taking other medicines that cause ECG changes (see section "Other drugs and Nolicin® ").
- In case of deterioration of vision or any other eye disorder, immediately consult an ophthalmologist.
- If you notice any signs of liver disease, such as loss of appetite, icteric coloration of the skin, dark urine, itching or abdominal pain, stop treatment and consult a doctor.
- If you notice signs of damage to the peripheral nervous system (neuropathy), such as impaired sensory and pain sensitivity, burning, tingling, numbness, weakness or decreased sensitivity to light touch, pain in the limbs, impaired balance and vibration sensitivity, you must stop taking norfloxacin and see a doctor. Nerve damage to the hands, arms, legs, or feet may occur in patients taking fluoroquinolones, including norfloxacin. Nolicin should not be used in patients with a history of nerve problems called peripheral neuropathy.
- If you feel sudden severe pain in your abdomen, chest or back, go to the emergency department immediately.

Children and teenagers

Nolicin contains 12000 FDC Yellow No.6, E110
Azo dye may cause allergic reactions.

Other drugs and Nolicin®

Tell your doctor what medicines you are taking, have recently taken or might take.
- Tell your doctor if you are taking any drugs that affect the rhythm of the heart: medicines belonging to the group of antiarrhythmic drugs (quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, dofetilide, ibutilide), tricyclic antidepressants, certain antimicrobials (macrolides) , some antipsychotics.
- Probenecid reduces the excretion of norfloxacin in the urine, but does not affect the serum concentration.
- If you are taking drugs such as antacids, sucralfate, drugs containing iron, aluminum, bismuth, magnesium, calcium, zinc, then the absorption of norfloxacin is reduced. Therefore, it is recommended to take Nolicin® two hours before or four hours after taking these drugs. This restriction does not apply to H2 receptor antagonists.
- Tell your doctor if you are taking medicines for chronic bronchitis and asthma (theophylline) or medicines that suppress the immune system (cyclosporins). Co-administration with Nolicin® may increase the likelihood of side effects due to a possible increase in the level of theophylline or cyclosporine in the blood. If necessary, the doctor will reduce the dose of medicines.
- If you take drugs that prevent blood clotting at the same time as Nolicin®, their effect is enhanced and bleeding may develop. The coagulogram (prothrombin time and other parameters of blood coagulation) must be carefully monitored.
- Didanosine should not be taken at the same time as or within 2 hours of taking norfloxacin. absorption of norfloxacin is reduced.
- The combined use of Nolicin® and corticosteroids may increase the risk of inflammation and tendon rupture.
- With the combined use of Nolicin®, the effect of certain drugs for the treatment of diabetes (sulfonylurea) may be increased.
- Do not take medicines for the treatment of bacterial urinary tract infections (nitrofurantoin) at the same time as Nolicin®, since the effect of both drugs is reduced when used simultaneously.
Co-administration of quinolones, including norfloxacin, with non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of CNS stimulation and seizures. Therefore, it is recommended to take Nolicin® with caution in patients simultaneously receiving NSAIDs.

Nolicin® with food, drink and alcohol
You can take Nolicin® on an empty stomach or with food. You should not take Nolicin® with milk or yogurt as liquid dairy products reduce the absorption of norfloxacin. Take Nolicin® one hour before or two hours after eating dairy products.
Some quinolones, including norfloxacin, inhibit the breakdown of caffeine, resulting in decreased excretion and increased plasma half-life of caffeine. This should be taken into account when drinking coffee and when taking medications containing caffeine.
During treatment, alcohol is not recommended.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you are pregnant, or are planning to become pregnant, consult your doctor before taking this medicine.
Pregnant women should not use norfloxacin, as there is insufficient information on the safety of the drug during pregnancy.
Do not breastfeed while taking Nolicin®.

Driving vehicles and working with mechanisms

Nolicin® may reduce alertness. You must be careful while driving or operating machinery until you know how the drug is affecting you. Adverse effects may be aggravated when combined with alcohol.

Application of the drug

Always take Nolicin® in full accordance with the recommendations of your doctor. If in doubt, consult your doctor.
The doctor will adjust the dose and duration of treatment in accordance with the disease. Always take 1 norfloxacin tablet with a glass of water or tea. Nolicin® can be taken with or without food. Tablets should preferably be taken at the same time of day. * Symptoms of urinary tract infections, such as burning or pain when urinating, fever, may disappear after 1-2 days. However, the recommended duration of therapy must be observed.
** If during the first 4 weeks of therapy the results of the required level were achieved, the daily dose of norfloxacin can be reduced to 400 mg per day. Currently, there is no information on the duration of therapy for more than 8 weeks.
Patients with impaired renal function
For patients with severe renal insufficiency (creatinine clearance ≤ 30 ml / min.), the recommended dose of Nolicin® is 1 tablet (400 mg) once a day.
Children and teenagers
Nolicin® should not be used to treat children and adolescents.
If you take more Nolicin® than you should
Report this to your doctor immediately. Too large doses can cause nausea, vomiting, diarrhea. In more severe cases, dizziness, fatigue, confusion and convulsions. If necessary, symptomatic and supportive therapy will be prescribed and adequate hydration provided.
If you forget to take Nolicin®
Do not take a double dose to make up for a missed one.
If you do not take a dose, take it as soon as you remember, unless it is time for your next dose.
If you stop taking Nolicin®
Take the drug as much as prescribed by your doctor, even if you feel better. If you stop treatment too soon, the symptoms of the infection may return.
If you have any further questions on the use of this drug, ask your doctor.

Possible adverse reactions

Like all medicines, this medicine can cause side effects, although not everybody gets them.
Very common: (may affect more than 1 in 10 people):
- changes in some indicators of the functional state of the liver;
- headache, dizziness;
- pain and cramps in the abdomen, nausea, heartburn, diarrhea;
- rash on the skin;
- fever.
Common (may affect up to 1 in 10 people):
- a decrease in the number of platelets (thrombocytopenia), a certain type of anemia (hemolytic anemia), sometimes in combination with a hereditary disorder of red blood cell metabolism (glucose-6-phosphate dehydrogenase deficiency);
- loss of appetite;
- sleep disorders;
- disorders of the nervous system (neuropathy), including Guillain-Barré syndrome (neuritis that begins with flaccid paralysis of the legs, which can spread to the arms), sensory skin disorders such as tingling and numbness (paresthesia);
- ringing in the ears (tinnitus);
- constipation, vomiting, flatulence, inflammation of the pancreas (pancreatitis);
- inflammation of the tissues of the kidneys (interstitial nephritis);
- severe skin reactions (exfoliative dermatitis, Stevens-Johnson syndrome, Lyell's syndrome and erythema multiforme);
- photosensitivity (for example, redness, swelling of the skin, blisters), itching, urticaria (rash), hypersensitivity reactions with swelling of the skin and mucous membranes (angioedema);
- worsening of myasthenia gravis, pain in muscles and joints, inflammation of the joints (arthritis);
- inflammatory vascular disease (vasculitis);
- itching, yellow skin or eyes, dark urine or flu-like symptoms, signs of liver inflammation (hepatitis, cholestatic hepatitis), including elevated levels of certain liver function tests;
- vaginal candidiasis;
- depression, anxiety / nervousness, irritability, euphoria (rapture), disorientation, hallucinations, confusion, mental disorders, including psychotic reactions.
Uncommon (may affect less than 1 in 100 people):
- changes in the number of certain blood cells (leukopenia, neutropenia, eosinophilia, decreased hematocrit);
- serious bowel disease with severe persistent diarrhea (pseudomembranous colitis);
- kidney failure, crystals in the urine causing pain and discomfort when passing fluid (crystalluria);
tendon inflammation, tendon rupture - especially the large tendon at the back of the ankle (Achilles tendon);
- severe acute hypersensitivity reactions with swelling of the skin and mucous membranes in the mouth and face and / or shortness of breath (anaphylaxis).
Rare (may affect less than 1 in 1,000 people):
- an increase in serum creatinine and urea, an increase in INR and prothrombin time;
- a disease of muscle tissue, accompanied by muscle weakness and pain (rhabdomyolysis);
- a certain severe form of inflammation of the liver (necrotizing hepatitis);
- fatigue;
- blurred vision, increased lacrimation.
Frequency not known (frequency cannot be determined from the available data):
- an abnormally fast heart rate, a life-threatening irregular heart rhythm, a change in heart rate (called a "long QT interval" seen on an ECG);
- impaired nerve conduction, which may cause weakness, tingling or numbness, and may be irreversible;
- hypersensitivity;
- yellowing of the skin (jaundice).
Reporting adverse reactions
If you experience any adverse reactions, please consult your physician. This recommendation applies to any possible adverse reactions, including those not listed in this package insert. By reporting adverse reactions, you help to get more information about the safety of the drug.

Nolicin® is the trade name for norfloxacin, an antibacterial agent in the fluoroquinolone class. The drug has a tablet form of release and is produced by the Slovenian pharmaceutical company Krka. The content of norfloxacin in the 1st tablet is 0.4 grams. The cost of packs of ten and twenty tablets in Russian pharmacies is about 200 and 370 rubles, respectively.

Nolicin ® is an antibiotic belonging to the group of gram-fluoroquinolones of the 2nd generation. The active ingredient of Nolicin ® is . Its difference from other 2nd generation fluoroquinolone antibiotics is that it creates significant bactericidal concentrations only in the gastrointestinal tract and genitourinary tract.

Pharmacological group

Fluoroquinolone antibiotics.

What does nolicin ® help with?

The drug Nolicin ® is effective against staphylococci (including methicillin-sensitive strains), gonococci, meningococci, Escherichia, Citrobacter, Klebsiella, Enterobacter, Proteus (including indole and indole + strains), Salmonella, Shigella, Yersinia, Campylobacter, Vibrio cholerae, Haemophilus influenzae, chlamydia, legionella. Enterococci, streptococci, serrations, mycoplasma, mycobacteria, pseudomonads have moderate sensitivity to norfloxacin.

Ureaplasmas, bacteroids, peptococci, peptostreptococci, fusobacteria, treponema, clostridia are completely resistant to the action of the antibiotic.

Nolicin ® - instructions for use in cystitis

Norfloxacin has a pronounced bactericidal mechanism of antibacterial activity, which is realized due to binding to DNA gyrase and inhibition of bacterial deoxyribonucleic acid. This leads to disruption of the process of supercoiling of the microbial DNA chain, its further destabilization and decay into smaller fragments.

Norfloxacin is well absorbed when taken orally, quickly reaching significant therapeutic values ​​in the gastrointestinal tract and genitourinary system. To ensure complete absorption of the drug, it must be taken sixty minutes before or 2 hours after a meal. To reduce the risk of developing undesirable effects from the use of Nolicin ®, it is necessary to consume at least 2 liters of water per day.

Utilization of the antibiotic from the body is carried out mainly with urine. A small part of norfloxacin is excreted in the feces.

The antibiotic is able to exhibit a bactericidal effect against aminoglycosido-, penicillin-, cephalosporin-, tetracycline-, macrolide- and sulfanilamide-resistant strains of microorganisms.

Also, due to the specific structure and mechanism of activity, norfloxacin is effective against bacteria that are resistant to nalidixic, oxolinic and pipemidic acids. Strains of microorganisms resistant to norfloxacin are also resistant to these drugs.

When using norfloxacin, there is a risk of developing cross-resistance to other drugs of the fluoroquinolone series. Cross-resistance develops as a result of mutations in the bacterial genes responsible for encoding deoxyribonucleic gyrase and topoisomerase 4, that is, targets for the action of fluoroquinolones change. Also, in addition to the main mutation, it is possible to change the permeability of the bacterial cell membrane to antibiotics of this group.

Release form Nolicin ®

Nolicin ® is available as a film-coated tablet. The content of the antibiotic in one table. equals 400 milligrams. The original drug is available in packs of ten and twenty tablets.

Photo of packaging of nolicin ® in tablets 400 mg, film-coated

In pharmacy chains, the drug is sold by prescription.

Recipe Nolicin ® in Latin

Rp: Norfloxacini
D.t.d: No. 10 in tab.
S: Inside according to the 1st table. every 12 hours

Composition of Nolicin ®

Each Nolicin tablet contains 0.4 grams of the active ingredient norfloxacin. As auxiliary components are indicated: dyes, thickeners, stabilizers, etc.

Nolicin ® - indications for use

Unlike other fluoroquinolone drugs, norfloxacin creates bactericidal concentrations only in the gastrointestinal tract and genitourinary system. In this regard, Nolicin ® can be used to treat patients with infections of the genitourinary system (including uncomplicated gonorrhea), shigellosis, travelers' diarrhea.

Also, the agent can be used prophylactically, to prevent the development of septic complications in patients with neutropenia.

Contraindications to the appointment of Nolicin ®

Like all drugs of the fluoroquinolone class, norfloxacin is not used to treat patients under the age of eighteen.

Nolicin ® is not used to treat women who are carrying a child and breastfeeding.

Hemolytic anemia, severe renal failure, porphyria, inflammation and tendon ruptures while taking fluoroquinolones, as well as individual hypersensitivity to fluoroquinolones or auxiliary components of the drug, serve as a contraindication to the appointment of norfloxacyan.

With caution, if absolutely necessary, the drug can be prescribed to patients with severe atherosclerosis, epileptic seizures, combined renal and hepatic insufficiency, malignant myasthenia gravis.

Also, care must be taken when prescribing Nolicin ® to patients:

• with arrhythmias, brady or tachycardia;
• with a decrease in potassium in the blood (hypokalemia);
• treated with antipsychotics, erythromycin ® , cisapride ® and tricyclic antidepressants.

Given that norfloxacin can affect the reaction rate, it is not recommended to drive a car and work with dangerous mechanisms during treatment.

Nolicin ® during pregnancy

All preparations of fluoroquinolones are contraindicated for use in women bearing a child. Strictly controlled studies on the safety of norfloxacin for the fetus have not been conducted. In this regard, Nolicin ® during pregnancy can be used only for health reasons, provided that there is no safer alternative.

Nolicin ® with breastfeeding is also not prescribed. If necessary, the appointment of this drug, you should transfer the child to artificial feeding.

How to take Nolicin ® ?

Nolicin ® for uncomplicated cystitis is taken 400 milligrams 2 times a day, in a course of 3 to 5 days. In acute UTIs (inf. Urinary tract), Wed also use 0.4 grams every 12 hours. The duration of the course is from seven to ten days.

Nolicin ® 400 mg instructions for use contain information that in chronic, often recurrent UTIs, the duration of the drug can be up to 12 weeks. At the same time, the first four weeks take four hundred milligrams of wed-va every twelve hours, and then according to the 1st table. in a day.

For the treatment of acute, uncomplicated forms of gonorrhea, a single dose of two or three Nolicin ® tablets (from 800 to 1200 milligrams) is recommended. Also, if necessary, the drug can be taken according to the 1st table. twice a day for three to seven days.

In case of infectious inflammation of the organs of the reproductive system, it is recommended to take norfloxacin from four hundred to six hundred milligrams every 12 hours for 7 days.

Patients with gastroenteritis of the bacteriological nature should consume 0.4 grams twice a day for five days.

In order to prevent the development of travelers' diarrhea, take one tablet of Nolicin ® before departure and continue the course (one tablet per day) until the end of the trip (the total duration of antibiotic intake should not exceed three weeks).

Norfloxacin may be prescribed to patients with neutropenic conditions in order to prevent the development of septic complications. In this case, Nolicin ® is prescribed eight hundred mg per day, divided into 2 doses, for up to eight weeks.

In order to prevent exacerbations of UTI, the drug can be prescribed at a dose of two hundred milligrams, once a day, the duration of treatment is set by the attending physician and depends on the frequency of relapses. If necessary, the duration of the reception can be up to six months.

Correction of the prescribed dose in patients with kidney pathologies is carried out depending on creatinine clearance.

Nolicin ® - side effects and side effects

Undesirable effects from the use of Nolicin ® can be manifested by disorders of the gastrointestinal tract of a dyspeptic nature, bitterness in the mouth, abdominal pain, antibiotic-associated diarrhea, pseudomembranous colitis, dysbacteriosis, thrush.

Also, it is possible to increase the indicators of liver transaminases in a biochemical blood test. Low fluid intake may cause crystalluria. Glomerulonephritis while taking Nolicin ® develop extremely rarely.

A characteristic complication that develops during therapy with any fluoroquinolones is photosensitivity. In this regard, during the treatment period it is recommended to avoid insolation and use creams with a high level of SPF protection.

With prolonged use, inflammation of the tendons and their rupture is possible (most often the Achilles tendon is damaged).

Also, allergic reactions, cardiac arrhythmias, arterial hypotension, convulsions, tremors of the limbs, anxiety and insomnia are possible.

Nolicin ® and alcohol - compatibility

Antibacterial drugs of the fluoroquinolone series are categorically incompatible with alcohol. Such a combination can lead to severe depression of the nervous system, up to coma.

It should also be borne in mind that the drug is excreted mainly by the kidneys, so Nolicin ® and alcohol, when taken simultaneously, can cause severe intoxication associated with impaired utilization of their metabolic products.

In patients with kidney or nervous system disease, the combination of fluoroquinolones with alcohol increases the risk of seizures.

It should also be noted that the intake of alcoholic beverages completely negates the effectiveness of the antibiotic. Therefore, such a combination is dangerous not only for its side effects, but also because it makes taking an antibiotic absolutely useless. In view of this, the progression of the underlying infectious-inflammatory disease (against which Nolicin was prescribed) and the development of purulent complications are possible.

The combination of norfloxacin and alcohol can also lead to toxic hepatitis and increase the risk of pseudomembranous colitis.

Nolicin ® analogues

As cheaper analogues of Nolicin ® containing norfloxacin, it is possible to use:

• Lokson-400 ® ;
• Normaks ® ;
• Norfloxacin ® (Vertek ® , Russia);
• Norfloxacin ® (Obolenskoye FP ® , Russia).

Nolicin ® or Monural ® , which is better?

It is impossible to say unequivocally which drug is better. Before choosing an agent for the treatment of cystitis, many factors should be taken into account, such as the age of the patient, the presence of various contraindications, pregnancy, the frequency of relapses, the sensitivity of the pathogen, the severity of the disease, and the presence of complications.

The drug of choice for the treatment of uncomplicated cystitis is. This drug is unique in its kind, as the course of treatment is one -2 days. Monural is well tolerated by patients and practically does not cause side effects during and after treatment.

Also, Monural ® can be used to treat children from five years of age and pregnant women.

The advantage of Nolicin ® is that it can be used for long courses to prevent exacerbations.

Latin name: Nolicin
ATX code: J01MA06
Active substance: Norfloxacin
Manufacturer: Krka, Slovenia
Pharmacy leave condition: On prescription

"Nolicin" is an antibacterial drug, belongs to the group of fluoroquinolones.

Indications for use

The drug is indicated for use in the treatment of infectious diseases of the genitourinary system, accompanied by an active inflammatory process, namely:

• Chronic form of prostatitis caused by bacterial flora
• Cervicitis, cystitis, and urethritis
• endometritis
• Pyelonephritis
• Gonorrhea (uncomplicated type).

Also, "Nolitsin" is prescribed for cholecystitis, for the treatment of bacterial gastroenteritis, gilmentoses.

Tablets can be used to prevent diarrhea, sepsis in patients suffering from neutropenia.

Compound

1 tab. the drug "Nolicin" contains 400 mg of the main active ingredient, represented by norfloxacin. The auxiliary components of the tablet include:

• Povidone
• Magnesium stearate
• Cellulose in microcrystalline form
• Silicon dioxide is colloidal in dehydrated form.

Medicinal properties

"Nolicin" refers to antimicrobial drugs, has a wide range of effects, including bactericidal. The mechanism of action of an antibacterial tablet is based on a violation of the integrity of the DNA of pathogenic microorganisms, which leads to their death.

The activity of the drug is aimed at a number of gram-negative bacteria, as well as some strains of gram-positive microorganisms, including Staphylococcus aureus and pathogenic flora that produces b-lactamase.

The activity of "Nolicin" in relation to the bacteria acinetobacter and enterococci was revealed, as a result of which it is possible to carry out effective therapy with the drug in diseases of the gastrointestinal tract.

Anaerobic bacteria, along with streptococci, are insensitive to the active substance of this drug.

Release form

Average price: 200 rubles

"Nolicin" is available in a single dosage form - tablets that are coated with p / o. Each tab. has a rounded, convex shape, the color of the shell is rich orange.

There are 10 tabs in one blister. The carton contains 1 or 2 blisters (respectively 10 tablets or 20 tablets).

Instructions for use of the medicinal product

Tablets are taken orally 1 hour before a meal or a couple of hours after a meal.

For infectious diseases localized in the organs of the genitourinary system, it is necessary to drink the drug 1 tab. (400 mg) twice a day after meals. The course of treatment is usually 7 to 10 days.

Instructions for using an antibiotic for cystitis

"Nolitsin" for cystitis (uncomplicated form) is usually prescribed to drink 2 tab. per day for 3-7 days. After completing the course of therapy, the doctor will be able to evaluate the effectiveness of the treatment and give recommendations whether you can take Nolicin further with cystitis or not.

With relapses of chronic diseases of the urinary system, the duration of treatment is usually 12 weeks. After completion of therapy, it is recommended to consult a specialist.

Treatment of acute gastroenteritis caused by bacterial flora: it is necessary to drink 400 mg tablets twice a day for a course of five days. In order to treat urethritis, pharyngitis, and proctitis, a one-time method of using the drug is recommended, which is based on the use of a dosage of 400 mg.

With helminthiasis, antibiotic treatment lasts 5 days.

Gonorrhea is treated for 3 to 7 days, you can use another method of therapy: take the pills once: a dosage of 0.8 g (2 x 400 mg) -1.2 g (3 x 400 mg).

Instructions for taking medication in case of disruption of the gallbladder: how to take "Nolicin" for acute cholecystitis

Antibacterial therapy for cholecystitis is used with other methods of treatment in combination. Before you start taking the drug, it is worth testing for the sensitivity of the bile flora to norfloxacincin. This testing method will help determine the effectiveness of antibiotic treatment for cholecystitis.

"Nolicin" or other antibacterial drugs that are part of the fluoroquinol group can be prescribed for cholecystitis only by a doctor. Therapeutic therapy for cholecystitis involves taking 400 mg (1 tab.) of the drug twice a day. How long the treatment will last in an individual case is determined by a specialist based on the available analyzes, as a result of which the therapeutic efficacy of the therapy for cholecystitis will be determined.

Instructions for using the drug for the purpose of prevention

Preventive measures aimed at preventing sepsis in neutropenia often last 2 months.

Prevention of travelers' diarrhea takes place with a daily dose of 400 mg (1 tab.). It is necessary to take the indicated dose of the drug the day before the intended departure, as well as throughout the entire duration of the trip and after 2 days after its completion. Therefore, it is better to initially purchase a package containing 20 tab.

During pregnancy and breastfeeding

To date, there is not enough information about the effect of the drug "Nolitsin" during pregnancy on the body of women and the fetus. The appointment of the drug in the early stages is possible only if there are "vital" indications in women, when the expected therapeutic effect on the mother's body significantly exceeds the existing risks for the child in the womb. Whether to take the medicine in early pregnancy or not, it is recommended to decide with your doctor.

For nursing, it is recommended to stop lactation for the duration of the treatment. The need for termination is explained by the fact that the active substance "Nolicin" penetrates into breast milk. The duration of use of the drug and its dosage in this case is determined by the doctor.

Contraindications

An antibiotic is not prescribed for the following conditions:

• Deficiency in the body of glucose-6-phosphate dehydrogenase;
• Pregnancy and lactation (for women during pregnancy, the use of the drug is prescribed strictly according to indications)
• Children's age (up to 18 years old)
• Excessive susceptibility to the components of the drug, as well as to other antibiotics of the fluoroquinolone group.

There are no other contraindications to taking antibiotics.

Precautionary measures

• Atherosclerotic changes in the vessels of the brain
• Epilepsy
• Impaired blood supply to the brain
• Allergic manifestations while taking acetylsalicylic acid
• Pathologies of the functioning of the kidneys, as well as the liver.

It is necessary to exercise careful control over the amount of fluid consumed (strict control of diuresis).

With painful sensations in the tendons or the first symptoms of developing tendovaginitis, the drug should be discontinued as soon as possible. Throughout the entire period of therapy, heavy physical activity should be limited.

Antibiotic treatment can interfere with blood clotting, so there is a need to monitor blood platelet levels both during and after treatment.

During the entire course of treatment, it is worth avoiding direct sunlight as much as possible on the skin.

The antibiotic can reduce the psychomotor reaction and the level of concentration, so you should avoid dangerous activities in which you need to quickly respond to what is happening.

Cross-drug interactions

The combination of an antibacterial drug with toefilin, as well as cyclosporine, increases their plasma levels.

Against the background of the combined use of "Nolicin" with warfarin, the effect on the body of the latter begins to increase.

The combination of taking this antibiotic with antacids, preparations containing iron and zinc, as well as sucralfate helps to reduce the absorption of norfloxacin.

Against the background of the combined use of quinols, corticosteroid preparations, the likelihood of tendonitis and tendon ruptures increases.

The simultaneous method of taking gopoglycemic drugs provokes an increase in the hypoglycemic effect of the latter.

The combination of norfloxacin and nitrofurantoin reduces the therapeutic effect of both drugs.

Side effects

Against the background of treatment with an antibacterial drug, a manifestation of a number of adverse reactions can be observed, which include:

• Gastrointestinal tract: frequent nausea, development of anorexia, impaired stool (diarrhea); increased activity of liver enzymes
• CNS: severe headaches, lethargy, excessive nervous irritability, depression, anxiety attacks
• Musculoskeletal system: quite rarely tendonitis develops, tendon ruptures occur
• Indicators of laboratory tests: the occurrence of leukopenia or eosinophilia, an increase in plasma creatine levels, a decrease in hematocrit
• Allergic manifestations: rashes like urticaria, development of anaphylactic shock, excessive itching.

With the development of adverse reactions, it is worth checking with the doctor whether it is possible to replace the drug with injections.

You can learn more about the symptoms of anorexia in the article:

Overdose

In case of an overdose, severe nausea, urge to vomit can be diagnosed. In rare cases, fatigue appears, frequent dizziness and convulsions occur.

There is no other way to treat an overdose.

Terms and conditions of storage

The antibiotic should be stored in a dark place at a temperature that does not exceed 20-25 C.

Tablets are stored for 2 years from the date of production.

Analogues

"Norbaktin"

Ranbaxi, India
Price from 83 to 282 rubles.

"Norbactin" is an antibacterial agent based on norfloxacin. The drug helps to cure bacterial infections of the genitourinary system and gastrointestinal tract. The drug is available in tablet form, 1 tab. contains 400 mg of active ingredient.

Pros:

• Low price for pills
• The antibiotic has a wide spectrum of action
• The antibacterial effect is observed quite quickly.

Minuses:

• Tablets are not prescribed during pregnancy
• Need a prescription to buy
• Against the background of application, allergic reactions may occur.

"Lebel"

Nobelpharma, Türkiye
Price from 752 to 1218 rubles.

"Lebel" is an antibiotic, which includes levofloxacin. The drug is active against gram-positive and gram-negative anaerobic microorganisms, effectively treats bacterial infections of the ENT organs and the genitourinary system.

Pros:

• Helps to quickly get rid of the symptoms of the inflammatory process
• The antibiotic is used in complex therapy for tuberculosis
• Available in two dosages, which facilitates the method of their application.

Minuses:

• High price
• The antibiotic is not prescribed for children under 18 years of age
• The drug causes multiple adverse reactions.

According to statistics, every third woman at least once encounters the symptoms of cystitis, and only six men out of a thousand are aware of its existence. This disease can be both acute and chronic.

Uncomplicated cystitis: Cystitis can occur as an independent, isolated, uncomplicated disease when it is caused by microorganisms that are present in the human body: streptococcus, E. coli, staphylococcus aureus. When favorable conditions arise for the reproduction of these bacteria, the body cannot cope with them, with their reproduction in the bladder. E. coli causes cystitis in 95% of cases, the remaining 5% are caused by saprophytic staphylococcus and other microorganisms. The provoking factors contributing to the occurrence of such cystitis are hypovitaminosis, hypothermia, stress, poor hygiene, change of sexual partner, and a general decrease in immunity.

Complicated cystitis: However, cystitis can act in combination with gynecological inflammatory diseases, with latent infections - sexually transmitted diseases (mycoplasma, gonorrhea, trichomoniasis, etc.), with pyelonephritis, with urolithiasis, it can be a complication, chronic tonsillitis, tuberculosis. For example, patients with chlamydial urethritis often develop not only cystitis, but also pyelonephritis. And also sometimes cystitis accompanies, it happens with injuries, anomalies in the development of the urinary system.

The insidiousness of this disease lies in the fact that with an incomplete examination, in the absence of finding out the exact cause of cystitis in a woman, and inadequate treatment, it will become chronic, with constant relapses, exacerbations when provoking factors occur. If permanent, chronic, how can she figure out what caused it and how to effectively cure it? Only after consultation with a gynecologist, urologist, if necessary, with an infectious disease specialist, having undergone a thorough examination and comprehensive treatment.

Tablets from cystitis Nolicin:

Consider how expedient it is to use Nolicin for cystitis. The active ingredient in Nolicin is norfloxacin, an antibiotic of the 2nd generation of fluoroquinolones. It has a pronounced antimicrobial activity, since it is a broad-spectrum antimicrobial drug.

Fluoroquinolones of the 2nd generation have been approved for use since the 80s, and are distinguished by good pharmacokinetics, high bactericidal activity, which allows them to be used in the treatment of infections of various localization.

Taking into account the peculiarities of distribution in the body, absorption, metabolism and excretion, Nolicin is used exclusively for infections of the urinary system, intestinal infections and prostatitis. However, any strong antimicrobial drugs, as a rule, have a number of contraindications and a wide range of serious side effects.

There are a lot of positive reviews about the effective treatment with Nolicin for cystitis in women. This is natural, since most strains of microorganisms to fluoroquinolones have not yet developed resistance, and this is a very powerful antibiotic.

In chronic cystitis, when most traditional drugs do not give a positive effect for the treatment of cystitis, it is advisable to use fluoroquinolones: Abaktal - pefloxacin, Ciprolet - ciprofloxacin, Nolicin - norfloxacin and others. The ideal ratio of effectiveness and cost is Nolicin tablets for cystitis.

Nolicin contraindications

• Children under 18 years of age, as its use is not recommended during the formation of the osteoarticular system.
• Pregnant and lactating women
• With a lack of glucose-6-phosphate dehydrogenase.

Use with caution in diseases:

• Hypersensitivity to norfloxacin and other fluoroquinolone antibiotics
• In violation of the blood circulation of the brain
• With liver and kidney failure
• With epileptic syndrome and epilepsy (see,)

How to take Nolicin for cystitis

Since the drug has many serious side effects, has a toxic effect on the liver, kidneys, is a broad-spectrum antibiotic, it is dangerous to take it on your own, without consulting a doctor. Its use is desirable in cases where other, less toxic drugs do not give a positive effect.

• For acute uncomplicated cystitis: With this course of cystitis, doctors recommend taking 1 tablet 2 r / d exactly after 12 hours course 3 days. A short course can only be used in case of mild cystitis, which is determined only by a doctor. At the same time, the effectiveness of therapy does not decrease, and side effects are much less common.
• Complicated, chronic cystitis: A short course is not suitable for women protected by spermicides, elderly women, with recurrent, chronic, complicated cystitis. In such cases, the course of therapy should be at least a week also one tablet in the morning and evening.

Features in the treatment of cystitis with Nolicin

• When ingesting fluoroquinolones, they should be taken with a full glass of water. Reception should be carried out separately from zinc, iron, bismuth preparations 2 hours before or 6 hours after them.
• Strictly observe equal intervals of time between doses
• Do not skip a dose, if missed, do not double the next dose
• Respect the duration of therapy
• Do not use expired medicine
• During therapy, drink enough liquid, at least 1.5 liters per day
• Do not expose yourself to direct sunlight or ultraviolet rays during treatment with Nolicin and for three days after the end of the course
• If pain occurs in the tendons, keep the joint at rest and consult a doctor
• Also consult a specialist if additional new symptoms appear and there is no relief on the 2nd day.

Side effects of Nolicin

• Digestive system: abdominal pain, loss of appetite, nausea, vomiting, with prolonged use, cholestatic jaundice, hepatitis, pseudomembranous enterocolitis may develop.
• Urinary system: polyuria, crystalluria, albuminuria, glomerulonephritis, urethral bleeding, dysuria, increased plasma creatinine.
• Musculoskeletal system: tendon rupture, arthralgia, arthropathy, myalgia, tendovaginitis, tendonitis.
• Nervous system: dizziness, headache, fainting, hallucinations, insomnia. In debilitated and elderly patients, it is also possible - drowsiness, fatigue, anxiety, fear, irritability, depression, tinnitus.
• The cardiovascular system: pressure decrease, arrhythmia, tachycardia,
• Allergic reactions: urticaria, pruritus, edema, Stevens-Johnson syndrome
• Hematopoietic system: leukopenia, decreased hematocrit
• Other: very often - candidiasis of the oral mucosa and, rarely, pseudomembranous colitis.

Price: in pharmacies, the average price for 10 tbl. 120 rub., for 20 tbl. 240 rub.

Nolicin for cystitis - reviews:

Please leave your feedback if you have taken the medicine for cystitis Nolicin, share with the readers your experience, the effect of the treatment, the side effects of the drug.